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Yu, Y. P. et al. Gene expression alterations in prostate cancer predicting tumor aggression and preceding development of malignancy.
Nevertheless, CK2 level is abnormally high in cancer cells where it is believed to generate an environment favorable to the development of malignancy, through a mechanism denoted as "non‐oncogene addiction".
But in the contrary, an inability of cancer cells to accumulate zinc has been found with the development of malignancy resulting in a dramatic reduction in the zinc content of prostate tissue.
Whether low-dose medical radiation exposure will result in the development of malignancy is uncertain.
Recent studies claimed that growth factor signaling is involved in tumorigenesis and the development of malignancy (Lee 2001).
Various theories have been put forward to explain the development of malignancy in these patients with previously resected choledochal cysts.
Basal cell carcinoma (BCC) occurs rarely in children and is most often associated with an underlying condition that predisposes patients to the development of malignancy.
Changes in extracellular matrices with an increase in collagen I and fibroblasts have been detected in herniosis, allegedly considered "hostile to the development of malignancy throughout the body" [3].
The phenomena of immune editing and immune evasion [25] must therefore be considered central to development of malignancy.
This silencing mechanism has been postulated as an early and age-independent event in the development of malignancy [35], [38].
Colonic inflammation has previously been shown to predispose to the development of malignancy, both in humans and in murine models of IBD [6], [21].
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