The development of lineage-restricted progenitors offers an opportunity to investigate mechanisms by which specific developmental stages can be paused.
To address this question, we consider two scenarios that could occur during early embryogenesis and the development of lineage-restricted TCSCs [ 1, 12, 13].
Despite the growing body of knowledge on the redeployment of shared genes for the development of lineage-restricted traits, key questions remain unanswered.
This has been the case of the pig, for example, where EBRs have been found to be especially rich in taste perception networks [ 49], suggesting that genome reshuffling significantly contributed to adaptation and the development of lineage-specific traits.
In particular, reconstruction of ancestral niches can provide testable hypothesis about the historical development of lineages.
Ancestral climate envelope reconstruction can provide testable hypotheses about the development of lineages.
But for a more robust system, stem cells, through the development of lineages, have choices - asymmetric renewal, symmetric expansion, and symmetric extinction.
In hospitals throughout the world, antibiotic pressure combined with the adaptive genetic capacity of S. aureus has resulted in the development of lineages with resistance to multiple antimicrobial drugs, including methicillin.
This mechanism of action was recently highlighted in neuronal development [ 74], heart and muscle development [ 75, 76], and in controlling the development of blood cell lineages [ 13, 20].
However, under similar conditions, another group reported a strong lineage bias against the development of T lineage cells from hESCs, and rather an NK lineage pre-disposition [15].
This common ancestry is potential evidence for location-specific development of H58 lineage II S. Typhi in typhoid-endemic regions of South Asia.
