The development of junction points, occurring during the crosslinking process with zinc ions, induced the increasing of free volume with following changing in chemico-physical properties of films.
The unabsorbed factor induced not only cell aggregation (as shown in the form of simple apposition) but also cell adhesiveness characterized by development of intermediate junctions, desmosomes and tight junctions, while the absorbed factor produced only simple apposition, suggesting their functional difference.
He was testing 400 proteins to see if they helped or hindered the development of specialized junctions between nerve cells, called synapses, which allow nerve cells to communicate with one another.
These data suggest that aPKCλ-defective cells show defects in the development of tight junctions.
Evidence in Drosophila suggests that total loss of the ZEB1 ortholog causes impaired development of neuromuscular junctions [45], [46].
Such a change is reflected even in development of tight junctions as demonstrated by immunohistochemical studies of claudins [19].
These genes may play important roles during the development of tight junctions and other processes of compaction.
The formation of cell cell contacts and the development of intercellular junctions with distinct structures like AJs and TJs is a step-wise process (Fig. 5).
Mutations that remove the part of LRP4 that anchors it to the cell membrane weaken this complex and thus reduce the development of neuromuscular junctions in mice, especially if the animals also lack amyloid precursor protein.
Recent studies [ 47– 49] have also suggested that FXYD-3 could regulate indirectly the development of tight junctions through its interaction with Na, K-ATPase, to promote cellular polarization and differentiation.
It is ubiquitously expressed in postmitotic cells and known to function during the development of neuromuscular junctions in the diaphragm and the proper formation of laminar structure in the cerebral cortex.
