Suggestions(2)
Exact(3)
Reasons for discontinuation appear to include lack of response, loss of response, development of intolerance, partial efficacy, and adverse events [ 61, 62].
The first article, by Nguyen and colleagues, looked at the relationship between blood glucose control and the development of intolerance to enteral feeding [ 3].
In chemical intolerance, researchers refer to "initiation" (the exposure that leads to the development of intolerance) and "triggering" (subsequent exposures resulting in symptoms); in addiction research, scientists refer to neurologic "sensitization" to a substance leading to "amplification" of its effects.
Similar(57)
In mice fed with high-fat diet (HFD), absence of AMPKα2 in skeletal muscle subunit led to a development of glucose intolerance and insulin resistance [6].
Saito T, Shimazaki Y, Kiyohara Y, Kato I, Kubo M, Iida M, et al. The severity of periodontal disease is associated with the development of glucose intolerance in non-diabetics: the Hisayama study.
The above results suggest that dietary nutrients contained in these hypercaloric diets might have an effect on insulin action and therefore, might contribute to the development of glucose intolerance and type 2 diabetes.
Our results identified CEP68 as a positive risk factor for the development of aspirin intolerance in asthmatics.
Therefore, we suggest that nicotine-induced mitochondrial damage has a significant role in the development of glucose intolerance in this animal model.
Mutations in these genes affect the levels of glucose and triglycerides and contribute to the development of glucose intolerance and insulin resistance in a response to high-fat diet [10].
Although no structural and functional changes have been described in the human pancreas, several studies suggest that, similar to what is observed in rodents; the nutritional status during the breastfeeding period in humans determines the development of glucose intolerance in adulthood [30] [32] and in turn predispose the development of type 2 diabetes mellitus.
Prospective studies investigating the impact of RBP4 on the development of glucose intolerance are needed.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com