Sentence examples for development of inhibitory activity from inspiring English sources

Others have reported the acquisition of antibodies that can block the activity of inhibitory antibodies [28], which may impede the development of inhibitory activity with increased exposure; presently, this effect is not well understood.

Our results provide a quantitative and mechanistic understanding of inhibitory activity of steroidal and azaheterocyclic AIs of relevance to adverse outcome pathway development and rational drug design.

(d) Dose-response curves of inhibitory activity of compounds 1, 2, 3 and 5 towards 3MST in the titration test.

The level of inhibitory activity against different isolates varied.

However, the degree of inhibitory activity was not determined.

D2 receptors have previously been shown to modulate GABAergic interneuron expression and function, thus suggesting that D2R activity alters the development of inhibitory circuitry.

Previous work in our group has identified inhibitors capable of dual inhibition of PfA-M1 and PfA-M17, and revealed further regions within the protease S1 pockets that could be exploited in the development of ligands with improved inhibitory activity.

Since macrolide antibiotics are known to target the 50S ribosomal subunit of the apicoplast to inhibit subsequent intra-erythrocytic development, we tested the invasion inhibitory activity of clindamycin, which has a similar mechanism of action and exhibits overlapping binding of the 50S ribosomal subunit of the apicoplast to azithromycin [ 39] (Table  1; Fig.  2c).

We speculate that strong activation of GPR43 by SCFA in differentiated Th1 cells may mask the effect of HDAC inhibitory activity, while HDAC inhibitory activity is dominant in SCFA regulation of naïve T-cells.

Compound 8 as such was devoid of HDAC inhibitory activity.

The results of antitumor inhibitory activity test showed that some compounds possess more potent antitumor inhibitory activity than 5-fluorouracil.