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A growing body of evidence suggests that Plk1 overexpression is tightly associated with the development of human cancers.
Although several papers regarding the relationship between MTUS1 gene expression and cancer have been published, the roles of MTUS1 in the development of human cancers (especially lung cancer) remain unclear.
Over the past years, a class of small, single-stranded, non-coding RNAs, known as microRNAs (miRNAs), have emerged as major regulators of the development of human cancers, including lung cancer (Guz et al., 2014; Kang and Lee, 2014).
The management of disseminated cancer have lately been done by molecular targeting strategies, based on the examinations of the oncogenes and tumor suppressors contributed in the development of human cancers [2].
There are four families of viruses that are now documented to be involved in the development of human cancers which include members of the polyomavirus, hepadnavirus, papillomavirus and herpesvirus families.
However, many questions still remain regarding the molecular mechanisms of polarity regulation and whether disruption of polarity protein function is an important step in the development of human cancers.
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Genetic and epigenetic changes contribute to deregulation of gene expression and development of human cancer.
Overexpression of Cas proteins contributes to the development of human cancer (reviewed in [3], [16]).
Both epigenetic and genetic changes contribute to development of human cancer.
However, it is generally assumed that the majority of chromosomal translocations responsible for the development of human cancer have already been described [8], [17].
Mutations of the genes involved in Wnt signaling cause congenital defects in humans, and inappropriate activation of the Wnt/β-catenin pathway has been linked to the development of human cancer [5] [7].
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