Sentence examples for development of histone from inspiring English sources

These findings will be useful for the further development of histone H3 peptide based LSD1-selective inhibitors.

In the past decade, although research and development of histone deacetylase (HDAC) inhibitors as therapeutic agents have achieved great accomplishments, especially in oncology field, there is still an urgent need for the discovery of isoform-selective HDAC inhibitors considering the side effects caused by nonselective HDAC inhibitors.

The potential therapeutic benefit created by facilitated gene transcription has led to the development of histone deacetylase (HDAC) inhibitors, which have the capacity to induce cytodifferentiation, and cause cell-cycle arrest and apoptosis of transformed cells (Marks et al, 2004).

The fact that DNA methylation does not appear to be critical to the development of histone modifications in X-linked gene expression should not be confused with a more important role for DNA methylation in maintaining repression of X-linked genes.

With the development of epigenetics, histone-modifying enzymes and ncRNAs have been found to play vital roles in regulating CSCs.

Taken together, these observations indicate that while the methionine metabolic pathway is not critical for wing development, direct regulation of histone methylation and demethylation plays an important role in the development of normal wing morphology in Drosophila.

The in vitro development, acetylation levels of histone H4 lysine 5 (H4K5), and octamer-binding transcription factor 4 (Oct-4) expression patterns of cloned embryos were systemically examined after various HDACi treatments.

Lot-to-lot variability, high costs and engineering difficulties are critical concerns for the development and commercialization of histone antibodies [ 12, 13].

In embryonic development, the formation of histone marks precedes and guides de novo DNA methylation, either by recruiting de novo DNA methyltransferase enzymes (H3K9 methylation) [ 24], or by protecting DNA from de novo methylation (H3K4 methylation) [ 25, 26].

Acetylation of transcription factors can either stimulate or silence gene transcription, and inappropriate acetylation levels have been associated with aberrant transcription of disease-promoting genes in cancer and inflammation, instigating the development of inhibitors for histone deacetylases (HDACs) (Ref. 7) and histone acetyltransferases (HATs) (Ref. 8).

Development of isoform-selective histone deacetylase (HDAC) inhibitors is of great biological and medical interest.