Sentence examples for development of gist from inspiring English sources

To date, no studies have investigated the involvement of hKs in the growth and development of GIST.

In conclusion, the variant KIT L541 was not found associated with increased risk of development of GIST but represents a predictive factor for relapse in localized GIST.

Regarding pathogenetic mechanisms implicated in the dual development of GIST and well differentiated NET in the stomach, data are still insufficient.

However, there is little information about the malignant development of GISTs.

These mutations lead to ligand-independent activation of KIT or PDGFRA, which plays an essential role in the development and progression of GIST (Heinrich et al, 2002, 2003).

Understanding the molecular physiology of GIST has allowed development of targeted therapies.

The development of nilotinib in the treatment of GIST was halted based on these results, but since nilotinib is well tolerated, it could have a niche in the treatment of patients who do not tolerate imatinib and whose GIST harbors KIT exon 11 mutation.

Molecular analyses of the c-kit and PDGFRα genes have contributed greatly to our understanding of the development of gastrointestinal stromal tumors (GISTs), but little is known about their malignant potential.

46, 47 The miR-135b was predicted as a regulator of the c-KIT gene, closely associated with the development of gastrointestinal stromal tumors (GISTs), 48 and this miRNA also regulates other genes involved in cancer occurrence, such as CASP10.

The close correlation between these markers and histological grade suggests that they play a role in the development of many of the non-GIST STSs, either through angiogenesis or other stroma-associated mechanisms.

These results have implications for the further development of treatments for drug-resistant GISTs.