Sentence examples for development of gallstones from inspiring English sources

Obesity, diabetes, and hyperlipidemia are known risk factors for the development of gallstones.

At the time their clinical relevance was not fully understood but we now know that bile acids are involved in vital bodily functions ranging from digestion to absorption of fat, while malfunctions in their mechanisms of action have been linked to increased cholesterol and heart disease, the development of gallstones, and even the onset of colorectal cancer.

Risk estimations for the development of gallstones were calculated as odds ratios (ORs) together with a 95% confidence interval (CI).

Furthermore, in previous studies low total cholesterol levels have been linked to the development of gallstones [41] but in our cohorts this was not the case.

Library SNPassoc was also applied in order to assess the effect of the rs9514089 polymorphism on the development of gallstones in multivariate models.

In the current study, we identified the polymorphism rs9514089 of SLC10A2 as the first intestinal bile acid related candidate for the development of gallstones.

While the vast majority of patients with gallstone disease should be managed by observation alone, selective cholecystectomy is indicated in defined subgroups of subjects, with an increased risk for the development of gallstone-related symptoms and complications in order to alleviate symptoms of pain, jaundice and to prevent acute pancreatitis, cholangitis and cholecystitis [2].

Chronic inflammation might play a key role in the development of gallstone.

Environmental and genetic factors, including female sex [ 8, 9], family medical history [ 10], age [ 11- 14], and estrogen-replacement therapy [ 15], contribute to the development of gallstone.

The development of the symptomatic gallstones is associated with obesity and alcohol use, likely because of their effects on serum lipids [ 17].

The biological link between metabolic syndrome and GSD has been attributed noticeably to Hch. 23 24 cholic acid, 9 the pronucleating proteins of IgM, 25 and T-cell function 26 have been presumed to be critical in the development of Hch; and gallstones have also been reported.