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These include the invention and improvement of novel inhaler devices as well as the further development of formulation principles and new powder engineering methods.
There is an emerging argument that HCMV vaccine efforts should focus on the development of formulation(s) which are designed to limit or prevent HCMV related diseases rather than to prevent infection itself [11].
Data obtained provide mechanistic information of importance to the development of formulation strategies for more effective intradermal and transdermal MN-mediated delivery of nanoencapsulated therapeutic agents.
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This requires development of formulations for targeted delivery.
The extent of prescription opioid abuse has led to the development of formulations that are difficult to crush.
Development of formulations and optimization of tableting conditions are intrinsically complex in nature leading to reliance on empirical methods in practice (Sun 2009).
The potential for process-induced solid phase transformations must be evaluated during design and development of formulations and manufacturing processes.
These challenges can be mitigated by modification of the manufacturing process and/or development of formulations to prevent degradation.
Examples of current approaches to the development of formulations of medications to decrease their abuse potential discussed in detail in the articles to follow are outlined.
The success of novel drug delivery systems depends on the development of formulations that are capable of improving the therapeutic index of biologically active molecules by increasing their concentration specifically at desired target sites or organs.
This influence is considered when the tip-speed-ratio is small, justifying the development of formulations that predict the effects of the wake on the rotor plane.
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