Sentence examples for development of efficacious therapeutic from inspiring English sources

Ultimately, the development of efficacious therapeutic interventions will likely need to consider host pathogen interactions to enhance host immunity and circumvent bacterial evasion strategies.

Genetic variability could also affect viral pathogenesis, development of vaccines, and development of efficacious therapeutic agents.

In an effort to improve survival in luminal-B breast cancer, there has been a recent focus on particular molecular pathways where development of efficacious therapeutic agents may alter the natural history of the disease.

Knowledge of significant signaling pathway networks will provide important clues and clear directions for an in-depth investigation of pituitary adenomas, for the discovery of tumor biomarkers, and for the development of efficacious therapeutic agents.

This understanding may help to reveal etiological factors as well as the development of more efficacious therapeutic interventions for a spectrum of patients that share common psychopathology involving sensorial experiences.

Thus, identification and characterization of these pathways is of major importance in improving our understanding of the pathogenesis of OA and may be helpful in the development of new efficacious therapeutic strategies.

Since cancer is generally considered a disease of the elderly, a more comprehensive understanding of how aging alters cellular function, and how alterations in cells and tissues impact on carcinogenesis, should contribute to the development of more efficacious therapeutic and prevention strategies for cancer [ 112].

We therefore postulated that by manipulating the nucleotide backbone and fine tuning the duplex stability through modified nucleotide chemistry, it may be possible to significantly modulate many characteristics of the system, such as binding affinity, specificity, stability, in vitro and cellular activity, which would be crucial for development of efficacious CRISPR-based therapeutic entities.

The selectivity profile of these compounds provides great improvement over the commercial drug tamsulosin, hence may pave the way to the development of new and efficacious therapeutic agents with reduced side effects.

This proof-of-concept study suggests that applying FUSION analysis to a larger, more diverse library of small molecules and/or crude natural product fractions could identify numerous lead compounds that are more specific inhibitors of AMPK or other therapeutic targets, leading to the development of efficacious targeted therapies.

Additional translational research investigating improved methods for discriminating DENV serotypes, the development of efficacious dengue vaccines and prospective clinical studies of novel therapeutic strategies are needed to improve the clinical outcome of DENV infection.