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The present results may be of relevance in the development of disturbances in the glucocorticoid as well as sex steroid balance among heavy female drinkers.
In accordance with this, our study subjects with NGT and metabolic syndrome had lower HIC compared with subjects without metabolic syndrome, suggesting that impairment of insulin clearance may occur before the development of disturbances in glucose metabolism.
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We did not observe the development of sensory disturbances with time in any patient suffering from classical TN.
In a later study, the same author (Mäkelä et al. 1989) showed that the size of the implant played a significant role in the development of growth disturbances.
It is a progressive neurodegenerative disorder that leads to gradual loss of cognitive and functional abilities, and development of behavioral disturbances.
The importance of IR as the primary etiological factor in the development of metabolic disturbances has increased the interest for measurement of insulin sensitivity.
At the same time, numerous epidemiological, clinical, and experimental studies demonstrate strong positive relationship between the intake of fructose and the development of metabolic disturbances [ 3– 16].
Children born SGA should not be allowed to gain weight too rapidly or excessively in an effort to circumvent the development of metabolic disturbances.
Some recently published trials also indicated that lifestyle modification and various pharmacological agents can delay or prevent the development of glucose disturbances to overt diabetes.
Therefore, we hypothesize that intramyocardial lipid accumulation and/or altered lipid metabolism may be involved in development of conduction disturbances in ZDF rats.
This suggests that mTOR may be a functional node linking mitochondrial dysfunction and ER stress susceptibility and thus influencing the development of metabolic disturbances.
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