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The development of dissemination nodules was analyzed 2 weeks after the cancer cell injection).
These results suggested that peritoneal lavage with DW during surgery for gastric cancer may be effective at disrupting exfoliated cancer cells and preventing the development of dissemination nodules.
A deeper understanding of the root causes of such differential risk behavior can help inform the development of dissemination strategies directed at different subgroups.
Furthermore, the development of dissemination nodules from gastric cancer cells was prevented by a preincubation with or peritoneal injection of DW.
These results suggest that the preincubation of gastric cancer cells with DW may markedly inhibit the development of dissemination nodules in nude mice.
Our results indicated that the development of dissemination nodules in vivo was prevented by the preincubation of gastric cancer cells with DW or peritoneal injection of DW.
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We also determined the efficacy of the peritoneal injection of DW for inhibiting the development of peritoneal dissemination nodules in vivo as a future treatment for patients with peritoneal dissemination from gastric cancer.
As patients with biliary tract cancers contain floating cancer cells in the bile [12], bile spillage potentially leads to the development of peritoneal dissemination [13].
The mice were sacrificed 28 days after the cell injection and examined for the development of peritoneal dissemination.
However, the effects of hypotonic treatments on the development of peritoneal dissemination from gastric cancer and their safeness in vivo have not yet been fully evaluated.
The disposition to integrate could be advantageous for cell survival and for the development of peritoneal dissemination and consequently could lead to more metastatic phenotypes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com