Sentence examples for development of disseminated from inspiring English sources

Since colonic diverticula are thin-walled and lack a muscular layer, cancers arising within a diverticulum can easily penetrate the serosa which may facilitate early development of disseminated disease.

Since cell motility and the consequent migratory and invasive potential are essential to the metastatic process, we used a preclinical model of metastatic neuroblastoma to investigate whether ICAM-2 expression affected the development of disseminated tumors in SCID mice.

ICAM-2 expression limited the motility of these cells and redistributed actin fibers in vitro, and suppressed development of disseminated tumors in an in vivo model of metastatic neuroblastoma.

The novel findings of this study are that neuroblastoma cells express ICAM-2 and that this expression is associated with juxtamembrane distribution of actin fibers, decreased cell motility in vitro, and suppressed development of disseminated tumors in a preclinical model of metastatic neuroblastoma.

However, the long and variable latency between exposure and development of disseminated disease in humans and primates suggests this disruption is incomplete in nature and raises the possibility that modulation of innate immune pathways as an important target for immunomodulatory therapy [7].

The development of disseminated intravascular coagulation (DIC) is associated with increased sepsis mortality.

The severity of bleeding can be augmented by the presence of active inflammation (confirmed also in our case), which may enhance through the production of proinflammatory factors of the local tissue coagulopathy [ 17] and switch to the chronicity with the development of chronic disseminated intravascular coagulation [ 18, 19].

The management of disseminated cancer have lately been done by molecular targeting strategies, based on the examinations of the oncogenes and tumor suppressors contributed in the development of human cancers [2].

Briefly, it involved adaptation of evidence-based practices for assessing, classifying and managing childhood malaria, pneumonia, diarrhoea and dehydration, malnutrition, anaemia, meningitis, neonatal sepsis and prematurity to the local situation with development of management protocols disseminated by the Ministry of Health.

No single channel of communication is sufficient when ensuring information related to child survival and development is disseminated widely.

Previous literature indicates that multifaceted, interactive, train-the-trainer workshops may be an effective means of disseminating and implementing professional development curricula (Pearce et al., 2012).