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The development of dengue therapeutics thus remains of utmost importance.
Major difficulty in development of dengue diagnostics is availability of suitable antigens.
These results may provide some important information for the development of dengue vaccine.
PRT in both eyes peaked at 3 weeks after the development of dengue fever and decreased during the subsequent 4 weeks, remaining unchanged thereafter.
Since this patient had developed retinal hemorrhages and mild optic nerve disorders, as well as microangiopathy noted on undus fluorescein angiography shortly after the development of dengue fever, dengue fever-associated maculopathy was diagnosed.
Although secondary infection with dengue virus is the most widely accepted risk factor for the development of dengue hemorrhagic fever, there is no simple, rapid, and reliable method that can routinely be used to discriminate between primary and secondary infections in the early days of an infection.
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13 Dengue warning signs (Box 1) in non-severe dengue may herald the development of severe dengue, thus forewarning clinicians to monitor their patients closely.
Regarding laboratory findings on admission, patients having >300 cells/μL of absolute atypical lymphocytes could be used to predict the development of severe dengue as patients with severe dengue had significantly greater levels of absolute atypical lymphocytes than patients with non-severe dengue.
Our study identified several clinical factors independently associated with the development of severe dengue among hospitalized adults with dengue.
In this study we evaluated the usefulness of the NS1 antigen detection test in predicting the development of severe dengue in adult patients with acute dengue infection.
Severe dengue is a highly pathogenic disease, so the development of a dengue vaccine is a high priority for protecting people at risk, but no safe vaccine is available at present.
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