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Dendrite morphogenesis is a complex but well-orchestrated process and includes the development of dendritic branches, forming characteristic dendrite arbors, and dendritic spines, allowing neurons to communicate with each other.
The adverse effects of malnutrition (PEM-stunting) on cognitive development could be related to the delay in certain processes of structural and functional maturation like delayed myelination and reduced overall development of dendritic arborization of the developing brain [ 1].
Structurally malnutrition results in tissue damage, growth retardation, disorderly differentiation, reduction in synapses and synaptic neurotransmitters, delayed myelination and reduced overall development of dendritic arborization of the developing brain.
In corticosterone-treated mice tracing of the apical dendrites of DG granular cells revealed a significant reduction in the development of dendritic spines that was reverted by Hypericum perforatum treatment.
In addition, CPEB regulates the transport of mRNAs in dendrites and disruption of CPEB function in frogs led to stunted development of dendritic arbors (Huang et al. 2003; Bestman and Cline 2008).
The development of dendritic cell (DC)–tumor fusion vaccines is a promising approach in cancer immunotherapy.
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Among the cancer therapeutic modalities discussed are chemoprevention, radiotherapy, radical retropubic prostatectomy, the development of dendritic-cell based vaccines, differentiation therapies, and gene therapy.
Cultures were maintained for 21 days to allow for the development and maturation of dendritic spines.
VEGF is a key mediator in the development and maturation of dendritic cells [17].
In particular, the overexpression of GluR2 induces the development and growth of dendritic spines in cultured hippocampal neurons [48], [49].
The other study [ 9], based on mostly qualitative criteria, also confirms that the major developments of dendritic branching are completed in the prenatal stage and also that some slow and subtle maturing consisting of secondary and tertiary branches continues into the postnatal period.
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CEO of Professional Science Editing for Scientists @ prosciediting.com