Specialised training for HRECs in this emerging area will help ensure the ethical conduct of research and is an essential component in the development of data linkage strategies in Australia if its potential is to be fully realised.
We used the provisional conceptual model to inform the development of search strategies, data extraction forms and a provisional framework for the statistical analysis of outcome data collected from the eligible studies (see Search methods for identification of studies and Data collection and analysis).
Typical challenges include the appropriate selection of analytical software tools, the speedup of the overall procedure using HPC parallelization and acceleration technology, the development of automation strategies, data storage solutions and finally the development of methods for full exploitation of the analysis results across multiple experimental conditions.
MT led the data collection, development of the search strategies, data analysis, and interpretation of results and drafted the manuscript.
A contemporary focus area for IM-MS research has been the development of acquisition strategies and data deconvolution procedures which extract additional information from partially resolved ion mobility data using the orthogonal information obtained from postmobility ion fragmentation.
The aim of the platform is to cover the lack of simulation platforms for on-board positioning systems, development of new data fusion strategies and test algorithms allowing faster improvements in this area.
Similar incentives could benefit the development of coherent data management strategies in the research practice.
The researchers will provide facilitation and support in the following ways: regular site visits (approximately one visit per month), analysis of peer-reviewed evidence to inform development of strategies, ongoing data analysis and feedback, report writing, organisation of site visit by relevant experts.
Margaret Sampson participated in the design of study, development of search strategy, data extraction, statistical analysis, and writing of the manuscript.
The disaggregation of data and development of different strategies are needed for both children and youth since each group has unique needs.
We are confident that the increasing sample size of GWASs, the growing number of publicly available GWAS datasets, the higher marker density and the development of novel strategies for GWAS data analysis will help isolate novel genetic signals related to AD in the future and might contribute to decreasing the missing piece of heritability in neurodegenerative disorders.
