Sentence examples for development of conditional from inspiring English sources
Understanding the development of conditional (if-then) reasoning is critical for theoretical and educational reasons.
Moreover, the recent development of conditional somatic mutagenesis in the mouse prostate offers the possibility to generate new models that more faithfully reproduce the human disease, and thus should contribute to improve diagnosis and treatments.
The recent development of conditional gene-targeting techniques in the mouse, based mainly on the bacteriophage P1 Cre/LoxP system, enable spatio- and/or temporal-controlled target gene ablation in the liver.
Development of conditional mouse models for Lrp6 and Lrp5 deletion will aid in the understanding of the specific roles of these proteins in mammary gland development and tumorigenesis.
The development of conditional transgenic strains in the mouse has particularly assisted in defining our existing understanding of ontological relationships during kidney development.
With the development of conditional knockouts, Xu et al. were able to demonstrate more elegantly and sensitively the cooperation between these two genes.
Protein stability can be efficiently controlled by conditional degrons, which induce target protein degradation at restrictive conditions.We used the yeast Saccharomyces cerevisiae for development of a conditional, bidirectional degron to control protein stability, which can be fused to the target protein N-terminally, C-terminally or placed internally.
To facilitate development of compound conditional cancer models, Lee et al. developed mice carrying a FRT-flanked p53 gene, which can now be combined with the Cre- loxP resources already available.
As the NMD pathway affects both mRNA isoform distributions as well as transcript levels, unraveling the underlying molecular mechanism(s) for the NMD requirement in proliferation will require full whole-transcriptome mapping studies of NMD deficient mammalian cells as well as the development of a conditional NMD null cell system amenable to rescue experiments.
The development of appropriate conditional models is crucial to advance our understanding of the molecular mechanisms underlying PTEN-associated carcinogenesis.
