The discovery of BRAF mutations in melanoma created the first opportunity to develop oncogene-directed therapy in this disease and led to the development of compounds that inhibit aberrant BRAF activity.
The area in which he gained the most recognition both in the US, and internationally was in the development of compounds that help preserve plastics against degradation.
Dr. Pedersen was noted particularly for the development of compounds called crown ethers that form complexes with particular ions, electrically charged molecular particles.
Experiments on four later flights focused on crystallizing extracts of an enzyme involved in Chagas' disease and on the development of compounds that might be useful in treating it.
These findings may inform the development of compounds to treat sleep disorders, since GABAergic neurotransmitter systems are a target of hypnotics and anesthetics.
The development of compounds that inhibit viral cap1 MTases has been, however, greatly limited by the lack of structural information about the corresponding human enzymes that must not be inhibited by the virus-specific drugs.
Our results provide insight into the design and development of compounds that can modulate bacterial chemotaxis and pathogenicity.
Thus, the development of compounds that are able to selectively interact with DAT is of great interest.
Major challenges facing the field include understanding of the factors determining the selectivity of kinase inhibitors and the development of compounds with the desired selectivity profile.
However, challenges remain in designing optimal proof-of-concept trials for the clinical development of compounds targeting the elimination of CSCs.
