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Further development of combinations of flexible and rigid components to dissipate or transmit stress could open up routes to more sophisticated mechanochemical reactions, or perhaps sequential reactions, simply by applying pressure to the sample.
This article reviews the recent advances in the design and development of combinations of pharmaceuticals for the treatment of lung cancer.
In the development of combinations, several aspects are often overlooked: (1) possible metabolic and biological interactions between drugs, (2) scheduling, and (3) different pharmacokinetic profiles.
This review describes the experimental studies involving metronomic schedules of chemotherapy, alone and in combination with angiogenesis inhibitors, and suggests a new therapeutic anticancer paradigm for controlling cancer by long-term therapy, based on the development of combinations of metronomic cytotoxic agents with individually tailored compounds designed to target specific molecules.
The parallels between clinical development of combinations and understanding of cancer resistance will ultimately lead to personalized medicine, such as matching targeted therapy with cancer patients based on molecular events underlying their malignancies.
Thus, development of combinations of drugs that induce MC, such as RT, deserves attention and should be tested clinically, due to the effectiveness of this mechanism to induce cell disruption.
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Public investment would likely be needed to help expedite the development of combination ARVs optimized for developing countries.
Second, the development of combination therapy.
They think the key to improving effectiveness will be the development of combination treatments, as happened with AIDS.
Only five years after the development of combination therapy for H.I.V., a large percentage of new infections are at least partly resistant to treatment.
Therefore, identification of targetable signaling pathways controlling colon cancer stem-like phenotypes will undoubtedly fuel the development of combination regimens to overcome current therapy limitations.
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