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Public investment would likely be needed to help expedite the development of combination ARVs optimized for developing countries.
Only five years after the development of combination therapy for H.I.V., a large percentage of new infections are at least partly resistant to treatment.
If results are similarly encouraging in human trials, this will help to accelerate the development of combination immunotherapy treatments using the antibody therapies already in the clinic, together with vaccines targeting the mutations present in individual cancers".
This explains the development of combination formulations.
Second, the development of combination therapy.
This increase in survival is largely due to the development of combination chemotherapy, which uses a number of different drugs.
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This article reviews the recent advances in the design and development of combinations of pharmaceuticals for the treatment of lung cancer.
In the development of combinations, several aspects are often overlooked: (1) possible metabolic and biological interactions between drugs, (2) scheduling, and (3) different pharmacokinetic profiles.
These improvements are considered to be a result of the development of combinations of standard chemotherapy, including fluoropyrimidine/folinic acid, irinotecan (FOLFIRI), and oxaliplatin (FOLFOX), and the introduction of new targeted biological agents such as cetuximab, panitumumab, and bevacizumab.
These results indicate that inhibition of the differentiation of monocytes to DC is a multifactorial effect, and that they support the development of combinations of angiogenesis inhibitors with immunological modulators.
Thus, development of combinations of drugs that induce MC, such as RT, deserves attention and should be tested clinically, due to the effectiveness of this mechanism to induce cell disruption.
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