Microglia often function as first responder cell type in the CNS that regulates the development of CNS inflammation (Nayak et al., 2012).
Thus, the decrease in αTocH correlated with infection itself and not the development of CNS disease, in contrast to afamin, which was decreased only in the animals that developed CNS disease.
In addition, we investigated the development of CNS related side effects and tolerance.
This chapter describes the role of adsorption, distribution, metabolism, and excretion (ADME) (i.e., pharmacokinetics) in the research and development of CNS therapeutics.
Recently the role of TRPC in the development of CNS was emphasized in many reports.
CCL2 and IL6 have been correlated with the development of CNS disease in HIV.
Both genetic and environmental factors may contribute to the development of CNS hypersomnias, as in the case of narcolepsy with cataplexy [5], [6].
During development of CNS Wnt signalling acts as important posteriorizing factor and correct anterior-posterior (AP) patterning requires anterior inhibition of Wnt pathway [2], [3].
This downregulation of cytokines and SIV in the brain is not sustained; increased expression can occur macaques with development of CNS disease by 42 days p.i.
Loss of heterozygosis determines the spontaneous development of CNS and PNS tumors with a penetrance close to 100% by the age of 6-7 months [18].
Premature truncation mutations in PS have been reported in early onset-AD cases, supporting haploinsufficiency or dominant negative actions as a possible pathogenic mechanism in the development of CNS disease [6], [7].
