Suggestions(2)
Exact(7)
Mutations in at least 20 different genes are known to lead to the development of CMS (Cruz et al., 2014).
We hypothesized that hypoxia-associated gene expression in children of men with CMS might identify markers that predict the development of CMS in adults.
In the present study, we identified miRNAs and their targets using high-throughput sequencing methods during reproductive development of CMS and its MF lines of B. juncea.
While R-lines have been developed that do restore complete fertility, the difficult task of continuing to make genetic progress in developing agronomically improved R-lines remains as the most significant obstacle in the continued development of CMS hybrid wheat.
Mutations in four other glycosylation genes (ALG2, ALG14, DPAGT1 and GFPT1) are known to lead to the development of CMS, and the symptoms of other glycosylation-CMS patients are similar to the symptoms of Case 1.
Regardless of how such biomarkers may have been induced, by epigenetic influences, evolutionary pressures or failure to respond to hypoxic stress, our findings point to an important role of particular genetic signatures in highland children for the later development of CMS.
Similar(53)
Alternatively, a persistently stressful environment could contribute to both the development of CM and depression [39].
"Even if we were to regroup and rebuild our own infrastructure, continuing development of CM would mean to operate with the threat of sale of the brand looming over our heads".
The Research and Development Division also offers consultancy, testing services, and strategic partnerships with local (Hong Kong), national (Mainland China), and international enterprises for the development of CM-related products.
In many studies, analgesic overuse has been identified as the most important risk factor for CDH and development of CM [3, 11].
Many modifiable factors influenced CDH progression and development of CM, analgesic overuse was frequently identified as the most important factor, and was seen in 95 (31.3%) of CDH patients (Table 2).
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