Sentence examples for development of checkpoint from inspiring English sources

Exact(1)

This has led to the development of checkpoint inhibitors as adjuvants to DNA damaging agents with the anticipation that they will enhance therapeutic activity.

Similar(59)

One of the major breakthroughs in oncology in the past decade has been the research and development of immune checkpoint inhibitors.

In recent years, the treatment of metastatic melanoma has changed dramatically due to the development of immune checkpoint and mitogen-activated protein (MAP) kinase inhibitors.

Dr. Allison's pioneering cancer research in the area of immunotherapy led to the successful development of immune checkpoint therapy and the first drug approved by the US Food and Drug Administration for the treatment of metastatic melanoma.

This review will summarise the mechanism of action and clinical development of immune checkpoint antibodies, as well as lessons learned in the management and assessment of patients receiving these agents.

Dr. Allison's work in the area of cancer immunotherapy led to the successful development of immune checkpoint therapy, and the first drug approved by the United States Food and Drug Administration for the treatment of metastatic melanoma.

The development of immunotherapy using checkpoint blockade has altered the treatment landscape for patients who had but few options only several years ago.

Finally, the lessons learned with CTLA-4-blocking antibodies have already proved critical to our understanding and further development of other immune checkpoint inhibitors.

Although treatment options for NSCLC are limited, a better understanding of the immune profile of this disease has facilitated the development of immunotherapeutics that target checkpoint blockade molecules, and clinical evaluation to date supports combining checkpoint blockade with chemotherapy for squamous NSCLC.

Moreover, the article by A. Ito et al. updates the readers on the clinical development of immunomodulators or immune checkpoint inhibitors.

More recently, the development of antibodies that prevent checkpoint-mediated inhibition of T cell responses invigorated the field of cancer immunotherapy.

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