This enables the development of causative, interpretive and reasonably predictive quantitative structure activity relationship models, and, hence, sound chemical information finalized to drug design and discovery.
Modeling has been successfully applied in physiology for many decades, but only recently the quality and the quantity of biomolecular data became available for the development of causative and predictive models.
Tuberculosis is an increasing threat, owing to the spread of AIDS and to the development of resistance of the causative organism, Mycobacterium tuberculosis, to the currently available drugs.
In comparison to the understanding of a single pathway, knowledge about the interplay of these important regulators of disease pathophysiology is of significant importance for the development of future preventive and causative treatment strategies.
Tetracyclines are generally used in the treatment of urinary tract and intestinal infections, and are used in the treatment of chlamydial infections, especially in patients allergic to β-lactams and macrolides; however, their use for these indications is less popular than it once was due to widespread development of resistance in the causative organisms.
The rennin-angiotensin system may thus be implicated in the development of microvascular dysfunction, but a causative mechanism cannot be ascertained from these data.
An editorial in the same issue of the New England Journal of Medicine makes a similar point the Danish researchers may have discovered a "new sentinel" for the development of asthma rather than a "causative signal," writes Erika von Mutius, a professor of pediatrics at the University of Munich.
As advances in our ability to identify the precise molecular bases of allelic variation continue to improve, the emphasis will shift from the development of linked anonymous markers to causative variation within genes, presenting particular problems in polyploid species, which will contain multiple very closely related genes that would interfere with assays.
By addition of silica-NPs to worms that already completed their development, e.g. adult hermaphrodites, we excluded interference of nanoparticles with vulva development as causative for the BOW phenotype (Figure 5C).
Identification of causative polymorphisms is important for the development of applicable genetic markers.
Congenital inability to feel pain is rare, but the identification of causative genes is translating into the development of novel analgesics.
