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Such widespread antimalarial drug resistance confirms the need to improve the efficacy of existing or new drugs as well as to develop alternative treatments through the identification of novel drug targets and the development of candidate drugs.
Biocompatibility is a critical factor in the design and development of candidate materials for biomedical use.
We conclude that IL-17A mediates pneumococcal immunity in mice and probably in humans; its elicitation in vitro could help in the development of candidate pneumococcal vaccines.
This study also allows the identification of limitations in current AMS materials, thereby informing the on-going development of candidate biodegradable alloys.
As part of the development of candidate reduced-activation ferritic steels for fusion applications, several steels, namely F82H, 9Cr 2WVTa steels and F82H weld metal, are being investigated in the joint DOE JAEA collaboration program.
In this paper, the experience gleaned from previous programs to develop materials for high temperature structural applications is used to identify and discuss some of the most critical issues that must be addressed in the development of candidate materials for fusion structural applications.
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The demand for an effective vaccine against Plasmodium falciparum malaria has stimulated the development of candidates targeted against pre-erythrocytic stages of the parasite, others against blood stages or toxins that cause disease, and yet more against the sexual stages [1].
After the initial study, 2 virus strains included in the panel (36 ) were selected for further development of a candidate IS for the WHO, and a candidate Japanese national standard (done in collaboration with the National Institute of Infectious Diseases in Tokyo).
The development of influenza candidate vaccine viruses (CVVs) for pre-pandemic vaccine production represents a critical step in pandemic preparedness.
We expect the further development of promising candidate circadian molecules, including nobiletin, in phase I human trials in the coming years.
During the development of the candidate materials, complex permittivity measurements of samples were obtained using complex reflection, transmission, and cavity measurement techniques.
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