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"Novartis is scary; Merck could become scary, Teva as well," Ms. Kulhoff said, noting the threat they pose to the companies that do the initial development of biologics.
Increased emphasis on the development of biologics has placed a significant focus on anti-drug antibody (ADA) detection.
Technological advances in the discovery and development of biologics have led to significant product and process improvement, affording drugs that are better for the patient.
This enabled us to compare the binding properties of these small-molecule inhibitors with durvalumab to investigate the hot spots on PD-L1 for future development of biologics for a better anti-tumor efficacy.
Increasingly, small (FIP) studies in the development of biologics are conducted in patients and information on drug effect is utilized to move directly to large dose-ranging studies.
In metabolic disorders such as the lysosomal storage diseases, the development of biologics such as enzyme replacement therapy has been quite fruitful.
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An improved understanding of the molecular and cellular events that occur during bone repair and remodeling has led to the development of biologic agents that can augment the biological microenvironment and enhance bone repair.
OCTGT has published guidance documents and developed innovative tools that are designed to aid the rapid development of biologic products for patient use.
In this review, the latest research in the development of biologic protease inhibitors is examined.
Tissue engineering follows the principles of cell biology, materials science, and engineering toward the development of biologic substitutes that can partly or entirely restore and maintain normal function.
The development of biologic agents represented a major advance in the treatment of RA.
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