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However, they do not faithfully mimic the growth and development of autochthonous tumors that occur in human cancer patients.
The FVB-huHER2 mouse, which is prone to the development of autochthonous mammary tumors driven by huHER2 expression, was used as a model with which to study active immunological strategies targeting the human HER2 molecule in a tolerant host.
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In 2013, it counted 4975 heads as a result of the adoption in Southern Italy of the Council Regulation (EC) No 1698/2005 to support rural development that includes the presence of autochthonous breeds in danger of extinction; this is funded by the European Agricultural Fund for Rural Development EAFRDD).
Genetically engineered mouse models (GEMMs) might offer an advantage over xenograft and chemically induced cancer models by providing an opportunity to study mechanisms of autochthonous cancer development and response to treatment in an anatomically restricted manner in mice that are neither tumor-prone nor immunosuppressed (Sharpless and Depinho, 2006).
We tested MMRi64 mainly in leukemia/lymphoma cells because the p53 pathway is critical for apoptosis induction, lymphoma development and restoration of p53 in mice leads to regression of autochthonous lymphomas.
Our results are, however, valuable for the development of a national monitoring program to detect autochthonous forest stands that are target areas for biodiversity conservation.
In this context, the vineyard could be a reservoir of autochthonous yeasts of oenological interest.
There were hints of autochthonous transmission.
We report a case of autochthonous gnasthostomiasis in Brazil.
The overall mean weekly incidence of autochthonous DF was 0.04.
After 2008, more cases of autochthonous leishmaniasis were reported [ 4- 6].
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