The development of animal models is progressing more slowly.
Thioacetamide (TAA) has been used in development of animal models of acute hepatic encephalopathy (AHE).
Development of animal models that can be used for tissue engineering experiments and mimic end stage arthritic diseases is needed.
Apart from manipulating the dopaminergic system, circadian rhythms and the immune system seem to be promising targets for the development of animal models for BD.
Experimental work (including radioactive handling, development of animal models, and in vitro and ex vivo analyses) were performed by VDR, FI, MM, and CGM.
Recently, the development of animal models for use in metastasis research has greatly increased; however, there is still a lack of models that sufficiently represent human cancer.
The continued development of animal models is vital for the understanding and treatment of the many diverse disorders that occur in women.
In parallel there has been interest in the development of animal models, which would permit a more direct evaluation of potential allergenic activity.
Development of animal models harboring mtDNA mutations is crucial to elucidating pathways of disease and as models for preclinical assessment of therapeutic interventions.
The molecular mechanisms underlying benign prostatic hyperplasia are obscure and the development of animal models to test novel treatment strategies is challenging.
Experimental work (including radiolabeling, development of animal models, in vivo studies, in vitro, and ex vivo analyses) and drafting its description were performed by QC, HW, LL, JOT, MHO, KJ, TT, HSA, and SSE.
