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Forced degradation studies are used to facilitate the development of analytical methodology, to gain a better understanding of active pharmaceutical ingredient (API) and drug product (DP) stability, and to provide information about degradation pathways and degradation products.
Many biological and pharmaceutical groups have already begun to perform the laboratory work in a meaningful way on herbal remedies like the development of analytical methodology from common herbal remedies [ 59, 60] and the toxicological evaluation of phytomedicine compounds [ 61, 62].
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The present research is part of a project dealing with the development of analytical methodologies mainly based on primary indicators, such as isotopic ratios of stable and radiogenic elements, for the authenticity and geographical traceability of oenological food, typical of the Modena district.
In the determination of bioactive compounds in natural products, sample treatment is a critical step and sometimes limits the development of analytical methodologies.
Her research lines are the fundamental study of the organic materials used as binders as well as the development of analytical methodologies for painting analysis using GC-MS, FTIR, thermo gravimetric and synchrotron radiation based techniques.
Understanding the in vitro routes of biological processing should help guide the development of analytical methodologies for the detection of endogenous adducts.
Regulatory requirements regarding the purity of chiral drugs have generally become stricter in recent years; therefore, the development of analytical methodologies to test for enantiomeric impurities in pharmaceutical formulations is of great importance.
Therefore, the development and optimization of analytical methodologies that allow their identification and quantification are of paramount relevance.
Most Strategic Environmental Assessment SEAA) research has been concerned with SEA as a procedure, and there have been relatively few developments and tests of analytical methodologies.
Development of suitable analytical methodology for monitoring the analytes in the selected matrix during the feasibility study and applicable for the eventual characterization of the candidate CRM.
In the present work, the development of an analytical methodology which combines bar adsorptive microextraction with microliquid desorption followed by high performance liquid chromatography-diode array detection (BAμE-μLD/HPLC-DAD) is proposed for the determination of trace levels of four parabens (methyl, ethyl, propyl and buthyl paraben) in real matrices.
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