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Scientists suspect that in some APOE4 carriers hyperactivity of the hippocampus early in life leads to this region's later dysfunction, which contributes to the development of Alzheimer disease.
Studying this mysterious condition may help researchers to understand the cellular events underlying the development of Alzheimer's disease.
It is also far enough "upstream" in the development of Alzheimer's to be a sufficient target for a cure.
New trials are being planned using anti-amyloid drugs to try to arrest development of Alzheimer's disease.
Treatments will have to be given early in the development of Alzheimer's and, at present, the onset of the condition is proving very difficult to pinpoint.
The new study is the first to find a connection between high homocysteine levels in healthy people and the later development of Alzheimer's.
"These findings are as close to evidence as we can get to show that this particular pathway is active in the development of Alzheimer's.
It suggests that the herpes simplex virus, which leads to cold sores, may be important in the development of Alzheimer's.
The lead researcher, Dr. Henry Rusinek of New York University, said his team chose to focus on the medial temporal lobe because earlier research showed it to be affected early in the development of Alzheimer's disease.
Doug Brown, director of research and development for the Alzheimer's Society, said: "We know that inflammation in the brain may contribute to the development of Alzheimer's disease, and so finding ways to treat this is a potential avenue for researchers.
At the early stages of the development of Alzheimer's disease the synapses – which connect the neurons in the brain – are destroyed, according to researchers at the University of New South Wales, Australia.
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