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Obtained results may offer new insights in the development of alterations in cardiac electrical activity of critical ill patients.
Obtained results may offer new insights in the development of alterations in cardiac electrical activity and thus heart lung interactions in critically ill patients.
Research indicates that anxiety during pregnancy may be a risk factor for the development of alterations in the mental health of the pregnant woman and of obstetric complications.
Zinc might play an important role in the development of alterations in keratinocytes with aging [ 24, 25].
The development of alterations in glucose metabolism results from the gradual fall in β-cell function occurring within a background of insulin resistance.
First, the cross-sectional nature of our study does not provide insight into the time course of the development of alterations in insulin secretion and insulin sensitivity leading to deterioration in glucose homeostasis; therefore, no conclusions regarding cause-effect relationships can be made.
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The solid line represents the development of alteration state in the mainstream, with individual red squares showing the state of the major tributaries.
Various mechanisms can be implicated in the development of these alterations, including endothelial dysfunction and failure of communication between endothelial cells, glycocalyx alterations, and altered interactions between the endothelium and circulating cells.
Figure 1 Principal mechanisms implicated in the development of microcirculatory alterations.
Recent clinical and animal studies identified candidate mechanisms that may mediate the development of cardiovascular alterations in the setting of IUGR consistent with the hypothesis of perinatal programming [11, 12].
Given the heterogeneous aspect of microcirculatory perfusion and the mechanisms involved in the development of these alterations, it is expected that classical hemodynamic interventions will only minimally affect the microcirculation.
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