Sentence examples for development of agents to from inspiring English sources

Chemoprevention is a strategy that aims to reduce the incidence and burden of cancer through the development of agents to prevent, reverse or delay the carcinogenic process.

The development of agents to prevent cancer requires an iterative process of target identification, preclinical testing, and early and late phase clinical trials to establish efficacy and safety.

These findings implicate abnormal betaAR-G protein coupling in the pathogenesis of the failing heart and point the way toward development of agents to inhibit betaARK1 as a novel mode of therapy.

The development of agents to target specific upstream genes and proteins potentially deregulated in prostate cancer also provides an opportunity for anticancer therapy for CRPC.

Thus miRNAs may represent an attractive therapeutic target, and warrant further development of agents to target MIR30A-mediated autophagy, which could have a significant therapeutic impact on CML.

Therefore, the elucidation of the mechanisms underlying VEGF/VEGFR activity in leukemia cells is necessary for the development of agents to be used in combination with/instead of standard chemotherapy.

This information should facilitate development of agents designed to prevent acute myocardial beta AR dysfunction during CPB, potentially leading to improved outcome in this high-risk population.

A better understanding of the interplay among these substances will assist in the development of agents designed to ameliorate or reverse chronic pain.

Advances in the understanding of IBD pathogenesis have permitted the development of agents (referred to as "biological therapy") directed against rational therapeutic targets, including TNF-alfa antagonists such as infliximab and adalimumab (Caprilli et al. 2005b).

Given the recent increase in the prevalence of obesity and the paucity of effective pharmacologic therapies, the development of new agents to treat obesity is of critical importance.

Further studies are needed to fully explore the biological importance of β-defensins in the epididymis, and may lead to the development of therapeutic agents to increase immunity against sexually transmitted pathogens, and development of male infertility and contraceptive agents.