Sentence examples for development of additional compounds from inspiring English sources

Taken together, the structures establish a framework for the development of additional compounds targeting E1 enzymes, which will display higher potency and selectivity.

The limited clinical efficacy of these drugs necessitates the development of additional compounds in order to effectively combat disease.

This extended validation requires the development of additional compound files which was outside the scope of this initial study.

Supporting Information pages S-10 through S-29 describe method development, performance, and qualitative analysis of additional compounds.

A number of additional compounds targeted to inhibit RAF kinases are in development that vary in their designs and specificity (Thompson and Lyons, 2005).

Although several drugs are in development, no approved therapies for TTR amyloid cardiomyopathy are yet available, so the identification of additional compounds that prevent amyloid-mediated cardiotoxicity is needed.

Synthesis of additional compounds.

Synthesis of additional compounds was carried out to probe the role of various groups on the parent compound.

In these cases, they contained traces of additional compounds.

This can be an important issue in early stage drug development wherein costly, time-consuming synthesis of additional compound would be pursued only if dictated by basic proof-of-concept studies in mice, prior to advancing to PICV, Pirital virus [37], or BSL-4 arenaviral hemorrhagic fever guinea pig models [38], [39], [40].

The PK profile of 5624 offered insights in the design and development of additional new compounds, derivatives of 1,2,4-thiadiazole, with desired PK properties.