Sentence examples for development of addiction from inspiring English sources

To further examine the role played by NMDARs in the development of addiction, and specifically its association to the mesocorticolimbic DA system, we developed an independent transgenic line in which the gene for NR1 was deleted in DA neurons by expressing Cre recombinase after the stop codon of the DAT gene locus.

The development of addiction is marked by a transition from recreational to uncontrolled drug use.

"Cocaine-conditioned odor cues without chronic exposure: Implications for the development of addiction vulnerability". NeuroImage : Clinical 8 (1): 652-659.

These results indicate that, during the development of addiction in humans, drug-associated stimuli acquire increasingly stronger incentive properties each time they are re-experienced.

He has a special interest in how changes in the brain during adolescence pose greater risk for the development of addiction and mood disorders.

Exposure to abused drugs and stressful experience, two factors that promote the development of addiction, also modify synaptic function in the mesolimbic dopamine system.

Not dissimilar to individuals who forgo job and family responsibilities due to various drug problems, during self-disclosure, these participants activated their Nucleus Accumbens -- the very brain region that lights up when someone takes cocaine or other drugs and is important in the development of addictions.

We combined elements of operant self-administration and the two bottle choice test to track the development of addiction-like behaviours in mice drinking a sweetened morphine solution (Fig 2A).

We utilized knock-in mice expressing a mutant recycling MOR (RMOR) that desensitizes and is internalized in response to morphine to show that facilitating MOR trafficking not only enhances morphine reward but, despite this, reduces the development of addiction-like behaviours.

(pp 345 353) The immune system and those parts of the nervous system that regulate immune responses play a role in the development of addictions, particularly in the context of stressful situations.

The neuroimmune system (i.e., the immune system and those components of the nervous system that help regulate immune responses), and in particular the innate immune system, play a role in the development of addictions, including alcoholism, particularly in the context of stressful situations.