Sentence examples for development of a salmonella from inspiring English sources
The development of a Salmonella Paratyphi human challenge model should expedite the development and evaluation of potential paratyphoid vaccine candidates, in particular by allowing the direct measurement of vaccine protective efficacy in a safe, reproducible host-relevant model.
To the Editor Our recent development of a human Salmonella Typhi challenge model provided a detailed description of the clinical profile and associated pathological changes seen during typhoid fever [ 1].
This paper reports on the development and validation of a Salmonella sp. detection system based on three detection levels.
In a similar fashion to the development of the Salmonella Paratyphi challenge strain (NVGH308), an isolate obtained from the blood culture of a clinical case of paratyphoid infection in Kathmandu, Nepal (NCT02100397), an ST313 isolate from the field could, in theory, also be isolated and manufactured to Good Manufacturing Practice standards for use in challenge studies.
Larsson, J. T. et al. Development of a new nomenclature for Salmonella typhimurium multilocus variable number of tandem repeats analysis (MLVA).
We speculate that our results will have important implications in the development of novel Salmonella vaccines utilizing CpG as an adjuvant.
An increased incidence of pork-related human salmonellosis in Denmark led to the development of a national control programme for Salmonella in Danish swine herds in 1993.
The role of MPK6 is also underscored by the fact that mpk6 mutant plants were significantly less resistant to Salmonella attack, allowing infection to occur significantly faster and the development of higher Salmonella levels inside Arabidopsis plant tissues (Fig. 6b c).
This is critical given the sample sizes required for vaccine efficacy trials (≈9,000 persons) and the long timelines (2025 2035) for the development of some Salmonella vaccines set out by Allan Saul (Novartis Institute for Global Health, Italy).
The major challenge in the development of live attenuated Salmonella vaccines is generating a safe yet immunogenic vaccine strain.
However, E. ictaluri ΔasdA01 was fully complemented by the Salmonella SD-asdA gene, allowing the development of a balanced-lethal system.
