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The participants agreed that development of a release limit is critical for controlling the product quality; however, the data utilized and procedure used to determine an appropriate release limit is not consistent.
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Right now this means injection every week or so, with the future development of a slow release formulation less often.
These findings may provide a new approach to the host-guest chemistry of cucurbit[n]urils for the development of a controlled release technology of weakly acidic agrochemicals to plant systems.
With the development of a controlled release tablet for Lisinopril, the patient would only have to take his medicine once in a day, because the tablet would release the drug constantly over the period of 24 hours.
These findings are also encouraging for the development of a sustained release system for radiolabelled IUdR for use in the treatment of intracranial tumours, particularly in the immediate postoperative setting.
The study proves that the IntelliCap® is a very beneficial tool to assess the extent of colonic absorption for drug and thereby providing the mandatory information to make a scientifically sound early GO / NOGO decision on development of a modified release dosage form.
The development of a modified-release (MR) dosage form starts with defining a target product quality profile based on the clinical needs.
The development of a slow-release application that keeps the local concentration of PTH for a long time was very efficient as shown later in [19] where the daily injection of PTH dissolved in gel medium allowed a slow release which caused 1.6-fold faster acceleration of teeth compared to daily injection of PTH dissolved in saline solution which did not cause any acceleration.
Development of a pre-release data checking procedure that selects published peer-reviewed manuscripts from a study and independently reproduces tables and statistical analyses using the data deposited in the repository.
Subsequent efforts focused on improving dosing convenience through development of an extended-release diclofenac sodium preparation.
The development of an extended-release formulation that could improve the bioavailability of NFX and reduce the administration schedule may improve the patients' comfort and compliance, resulting in lower discontinuation of the therapy, with consequently a decrease in bacterial resistance.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com