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The development of a novel class of antibiotics has therefore become a major research theme.
Applications of this work to the development of a novel class of dimerization-modulating drugs are also discussed.
These compounds should prove useful for elucidating RGS-mediated activity and serve as a starting point for the development of a novel class of therapeutic agent.
This compound represents a novel donepezil hydroxyquinoline hybrid with DMAAD profile paving the way to the development of a novel class of drugs potentially able to treat AD.
The chemical scaffold we here describe can be utilized as a lead-generating platform for the design and development of a novel class of anti-cancer agents.
Advances in microelectomechanical systems (MEMS) have allowed the microfabrication of polymeric substrates and the development of a novel class of controlled delivery devices.
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A major breakthrough in this approach came from the development by AstraZeneca of a novel class of MCT1-specific inhibitors [ 24].
Chemical space projection of the synthesized compounds along with 3067 structures with known activities against T. cruzi shows that the isoquinolones occupy a sparsely-populated region of chemical space, indicating their potential for development as a novel class of trypanocidals.
Strategies to restore apoptosis have led to the development of BH3 mimetics (a novel class of therapeutics – now in clinical trials) designed to inhibit the interaction between Bcl-2 family members at BH3 domains (Zhang et al, 2007; Lessene et al, 2008; Kang and Reynolds, 2009).
Discovery of sexual development in the ascomycete Trichoderma reesei (Hypocrea jecorina) as well as detection of a novel class of peptide pheromone precursors in this fungus indicates promising insights into its physiology and lifestyle.
The labyrinthopeptin A1 (LabyA1) is a prototype peptide of a novel class of carbacyclic lantibiotics.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com