Sentence examples for development of a hereditary from inspiring English sources

But such a commitment to freedom turned out to be a smoke screen for the development of a hereditary dictatorship.

Another possible explanation is that any differences in NBEC from BC individuals compared to non-BC individuals resulted from development of BC, instead of being a hereditary cause of increased risk for cancer.

These data constitute the first proof of concept of the feasibility of the use of an iPSC and its genome-corrected counterpart to unravel the molecular mechanisms underlying the development of the hereditary MEN2A cancer predisposing syndrome.

Mutations of succinate dehydrogenase (SDH) have been implicated in the development of a cancer syndrome referred to as hereditary paraganglioma and pheochromocytoma (HPGL).

Moreover, kif5a mutations are associated with the development of hereditary spastic paraplegia (SPG10), a neurodegenerative disease.

Researchers have established that these genes can also be involved in the development of non-hereditary, sporadic tumours, as a proportion of ovarian and breast cancers contain somatic (tumour only) BRCA1 and BRCA2 pathogenic variants [ 5- 15].

Li and Fraumeni Jr. proposed for the first time in 1969 the theory of a hereditary cancer syndrome characterized by the early development of multiple tumors [ 57].

A link between grm1 overexpression and the development of hereditary melanoma was demonstrated by the targeted expression of murine grm1 cDNA under a melanocyte-specific promotor (dopachrome tautomerase; DCT) [ 23].

This suggests that PARG110 is of major importance for maintaining the activity of PARP, and in turn highlights PARG inhibition as a novel approach for the development of therapies for hereditary RD.

This group of breast cancer patients was selected for mutation analysis of the BRCA1 and BRCA2 genes, because a positive family history and/or diagnosis at young age is a significant risk factor for the development of hereditary breast cancer (Claes et al, 1999a, b).

A role of E-cadherin mutation in development of hereditary gastric cancer has been shown, but its role in predisposing to breast cancer is still unproved.