Exact(5)
SeDeM system is a step forward in the rational development of a formulation, allowing the normalisation of the rheological parameters and the identification of the weaknesses and strengths of a powder or a powder blend.
Specifically, we elaborate on the components (choice of lipids, molar proportions, etc)., methods (preparation of liposomes, drug loading methods, etc)., critical design features (size, surface charge, etc)., and key biological endpoints (circulation lifetime, bioavailability, efficacy measurements) important to the development of a formulation of vincristine with enhanced therapeutic properties.
Moreover, the development of a formulation for topical use containing the combination of compounds/oils described could also be advisable.
Translation of this insight into the clinic will involve the development of a formulation suitable for depot ICG application in humans.
In summary, our studies provided rational evidence on total flavonoids of Cotinus coggygria for further preclinical development of a formulation that preferentially targets alternative cell death pathways to improve therapy in glioblastoma treatment and to achieve better preclinical outcomes.
Similar(55)
At the heart of individual CBT is the development of an individual formulation (the formulation-based approach) in collaboration with the client.
Hence, QSPR approach saves resources by predicting drug release from an unformulated formulation; avoiding repetitive trials in the development of a new formulation and/or optimization of existing one.
In the absence of any highly effective vaccine candidate against Plasmodium falciparum malaria, it remains imperative for the field to pursue all avenues that may lead to the successful development of such a formulation.
Gilead said it initiated development of a second formulation of its Truvada drug and Sustiva, which is made by Bristol-Myers.
These could be process variable ranges during the development of a pharmaceutical formulation following the quality by design (QbD) approach.
However, successful implementation of entomopathogenic activity shown at laboratory level to field scale necessitates the development of a suitable formulation (Amutha et al. 2010).
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