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This study describes the development of a DNA microarray for detection of several species belonging to the genus Alexandrium.
This proposition led to the development of a DNA enzyme identified from a library of >1,000 different DNA molecules by successive rounds of in vitro selective amplification.
These results provide evidence for the development of a DNA vaccine targeted against DKK1 to attenuate bone erosion.
In addition, logistic regression analysis allowed for the development of a "DNA damage index" to assess the effects of contaminants on the gill.
The demand for a comprehensive repeat analysis prompted the development of a DNA microarray-based assay to study the occurrence of hundreds of repeats in twenty plant genomes [ 13].
In this first issue of the year, we draw your attention to four contributions related to the topic of New Targets : nicotine vaccines (reviewed by Goniewicz, p), plant-derived VLP vaccines (reviewed by Chen, p), clinical trial data of a poxvirus-vectored candidate tuberculosis vaccine (Rowland, p), and preclinical development of a DNA vaccine against Clostridium difficile (Jin, p).
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We considered several key issues regarding the development of a DNA-based human immunodeficiency virus type 1 (HIV-1) vaccine: (1) should the candidate vaccine construct be derived from incident or prevalent HIV-1 strains; and (2) should circulating plasma virus, archived HIV-1 provirus recovered from peripheral blood mononuclear cells, or both be included?
Additionally, the development of a DNA-based assay that can serve as a molecular diagnostic test for osteopetrosis carriers will facilitate the eradication of this disorder from the Red Angus population while minimizing loss of genetic merit.
This study reports the development of a DNA-based HRD score based on genome-wide LOH analysis of ovarian tumours combined with comprehensive profiling of BRCA1 and BRCA2 defects.
Since 2003, substantial effort has been directed toward the development of a DNA-based identification system for animal life, based upon the analysis of sequence diversity in the 5' region of the mitochondrial gene, cytochrome c oxidase 1 [ 1, 2].
Center research has led to the development of a DNA-based Pseudo-nitzschia-specific ARISA for species identification, which is used in tandem with environmental clone libraries for strain identification and to assess the diversity of Pseudo-nitzschia communities [ 75].
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