Additionally, obesity results in the development of a difficult-to-control asthma phenotype in which patients experience worse clinical control, poorer quality of life, reduced lung function, poor responses to corticosteroids and more psychosocial symptoms [ 11– 11].
The advantages of this system enable analysis of htt function at the earliest stages of development, a difficult task in mouse Hdh knockout models.
"The recent introduction of targeted tax allowances to promote the development of a range of difficult projects, coupled with the government's ground-breaking commitment to provide certainty on decommissioning tax relief, has prompted global companies and independent businesses alike to take another look at the UK as an investment destination," Mr Webb said.
As we all know, the transient character of the postdoctoral experience, coupled with the typical attachment of the postdoc to a particular research laboratory and faculty member, makes any development of a postdoctoral community a difficult prospect.
The development of a vaccine is especially difficult because it will need to counter all four types of virus.
Some of the drugs being developed, such as kinase inhibitors, have multiple targets and development of a predictive biomarker is made difficult by uncertainty in the molecular basis for anti-tumour effect.
This makes the development of norms difficult [ 5], and may allow a service to be complacent about low levels of service.
The main drawback of the simulation of application's software using an accurate model of the processor resides in the development of a handwritten simulator which is a difficult and tedious task.
Yet, from the apparently 'desolate' north, to the Tory front line of the home counties, political priority is given to the development of shale gas, a difficult, dirty and inefficient fuel to exploit, whose extraction will accelerate climate change.
These different objectives make the development of a single measure of quality difficult.
The development of a shape meter is so difficult that it has been monopolized for a long time by Sweden's ABB, Germany's SIEMENS, SUNDWIG, and other international companies [83, 84, 85, 86, 87].
