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The development of a compound that tackles the disease in mice, and the identification of the protein it targets, offer a way forward.
Our systematic and continuous study in this field lead to the development of a Compound Parabolic Concentrator (CPC) based photocatalytic hydrogen production solar rector for the first time.
If we could find just that special subunit of taxol that's required, that would greatly simplify synthesis". Another promising laboratory-based approach is the development of a compound closely related to taxol, called baccatin, which is produced in the leaves of taxus baccata, the English yew.
Development of a compound that regulates neuronal cell death is a plausible therapeutic strategy to slow or halt the progression of neurodegenerative disease.
Such information is essential to the development of a compound toward phase I clinical trials.
Drugs of lower molecular weights more easily cross the embryonic blood-brain barrier, a factor to be taken into consideration when evaluating the impact on brain development of a compound given systemically.
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Due to its similarity to parkinsonian disorders and the examination of cases of human toxicity of MPTP, this compound has been extensively studied, making it an excellent candidate for the development of a compound-specific PoT.
In 2010, Lilly halted development of a different compound, semagacestat.
The results reported here may help the development of a lead compound for the treatment of RSV infections.
Structure-guided optimization of a 5-substituted-3-thiophene carboxylic acid screening hit (3a) led to the development of a lead compound (12b), which shows inhibition in both enzymatic and cellular assays.
This resulted in an unprecedented effort to measure and publish bioactivity data, and the development of a unique compound collection, known as the Molecular Libraries Small Molecule Repository (MLSMR).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com