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However, cart1 is known to be essential for normal skull bone development, null mice develop with normal limbs and trunk, but the interpatietal and majority of the parietal and frontal bones are absent [65].
PPARγ, a ligand-activated nuclear receptor, plays essential roles in placental development; null murine embryos die at midgestation due to abnormalities in all placental layers, in particular, small labyrinth and expanded giant cell layer.
The Atf4 gene in flies is essential for normal development; null mutants for Atf4 are lethal (Hewes et al. 2000).
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Survivin is essential in suppressing apoptosis during mouse development, Survivin null mice are lethal at early embryonic stage (Uren et al., 2000).
During development, E2f4 null mice have severe disruption of liver-based erythropoiesis [17].
All tests required the development of null matrices through constrained randomizations of the species by site matrix.
Mosaic analysis during pupal development reveals null R cells are that disorganized (Fig. 6C E arrows) within omatidia comprised of wild-type supporting cells.
The development of null mutants of both dPGM and iPGM in E. coli makes possible a whole organism screen for identification of potential inhibitors with specificity for iPGM.
TORMOZ (TOZ, At5g16750) is a nucleolar protein, required for cell division patterning, at least during embryo development (no null allele have been characterized), that may be also involved in rRNA biogenesis [7].
While AMPK is clearly required for normal development, as null mutants are larval lethal [9], we note that induced transgene expression in adults leads to reduced survivorship during starvation.
All other studies investigating visual development had null results.
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