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Identification of epitopes on viral proteins for the design/identification of broadly-neutralizing monoclonal antibodies (bnAbs) or specific immunogens for vaccine development is hampered by target amino acid diversity.
Analyses of early mouse development is hampered by the inaccessibility of the early embryo and the limited amount of tissues at these stages.
However, the development of appropriate clinical interventions and health systems development is hampered by a lack of locally-generated data.
There is no therapy for CADASIL, and therapeutic development is hampered by a lack of feasible clinical outcome measures and biomarkers, both in mouse models and in CADASIL patients.
However, this development is hampered by the difficulties that accompany the assessment of molecular mechanisms and pharmacological actions of multicomponent preparations that contain an enormous chemical diversity of substances [ 1- 3].
This has important implications especially for Afghanistan, as development is hampered by a myriad of factors including an unstable political system, poor economy, and ongoing violence, which negatively influence health care provision [ 21].
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His development was hampered by a hamstring injury sustained during the off-season camps.
Instead, he focused on Africa, calling it a "continent that is full of promises" but adding that its development was hampered by climate change, war and terrorism.
But whereas the Cali mob did much for its city's economic rise before 1995, Medellin has historically been a business power-house, whose development was hampered by Escobar's murderous reign.
The idea of the program originated in the 1930s, but its development was hampered by a Federal Communications Commission rule that required stations to identify recorded music frequently so frequently, as it turned out, that the message tended to irritate and alienate the listener.
The Siemens (now Avid) compound 18F-T808 showed good preclinical properties as well as good pharmacokinetic characteristics in a first-in-human study, although development was hampered by strong defluorination (Chien et al. 2014).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com