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For example, in the absence of functional Stat5a, mammary development is abrogated and mice do not lactate [ 17].
Our data suggest that reduction of NOTCH3-signaling by physiological downregulation of MSX2 expression during T-cell development is abrogated by ectopic expression of oncogenic NKLs, substituting MSX2 function.
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However, disease development was abrogated only in mice treated with CXCL10 neutralizing antibodies, whereas CXCL9 neutralizing antibodies had no effect on disease development [ 40].
Thus, in the oestrogen responsive tumour cell, growth is abrogated.
Interestingly, IL-1Ra-deficient mice present increased number of Th17 cells, and spontaneous development of arthritis is abrogated when associated with IL-17 deficiency (or IL-17 neutralization) [ 140, 142], demonstrating the great involvement of Th17 cells in this IL-1-driven arthritis model.
Capsaicin promotes DC maturation, which is abrogated in TRPV1−/− DC cells.
67 These findings suggest that regulating the amount or the ratio of C/EBPβ isoforms might be a common pathway that is abrogated during the development of AML.
PMN infiltration towards LPS is abrogated in Mmp8-null mice.
This response is abrogated in Tlr4-defective mice.
This effect is abrogated by dexamethasone.
This deleterious effect is abrogated by effective antibiotic therapy.
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