DOI: http://dx.doi.org/10.7554/eLife.06132.002 The invariable development of drug resistance presents a critical challenge to the success of targeted cancer therapies (Jänne et al., 2005; O'Hare et al., 2006; Poulikakos and Rosen, 2011).
However, the invariable development of drug resistance greatly limits the effectiveness of this therapy, despite efforts to circumvent acquired genetic abnormalities, such as the recurrent T790M-EGFR gatekeeper mutation or MET amplification.
By adulthood, bronchiectasis is invariable and many patients develop respiratory failure [ 4].
The β-subunit appears to have invariable domain architecture throughout evolution and its invariable nature is due to functional rather than structural constraints.
Furthermore, this study shows the invariable occurrence of DD/ID and the occasional (8.8%) development of hepatoblastoma, thereby showing the necessity of adequate support for DD/ID and screening of hepatoblastoma in affected patients.
However, nucleosome density appears to be largely invariable except for limited changes in response to signaling or development [ 14, 48].
We also show that this process is accompanied by series of long-range contacts with the flanking gene deserts, even though these contacts remain largely invariable throughout temporal colinearity, unlike what was observed during limb development (Andrey et al., 2013).
63 The main advantage of genetic variants is that they remain invariable throughout life, so it is possible to determine a person's genetic risk profile before the development of an adverse cardiovascular risk factor profile, which would allow primary prevention measures to be undertaken earlier in life.
"Like Obama!" is the invariable response.
Adverbs, prepositions, conjunctions, and interjections are invariable.
