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Ultrastructural analysis confirms that myosin-rich thick filaments enter submembranous regions and interfere with synaptic development, indicating that the disorganized myofilaments may cause the synaptic growth phenotype.
Further, genetic engineering in mice adding T cells that recognize the same myelin antigen resulted in spontaneous EAE development, indicating that the coexistence of myelin-specific B cells, T cells, and antibodies was sufficient to trigger CNS autoimmune disease.
The effects were not immediately apparent (PN5) but rather emerged over the course of development, indicating that the organophosphate effects represent alteration of the trajectory of development, not just continuance of an initial injury.
While significant deviations in air temperature have been noted around the time of Mediterranean tropical cyclones' formation, few anomalies in sea surface temperature coincide with their development, indicating that the formation of medicanes is primarily controlled by higher air temperatures, not by anomalous SSTs.
Moreover, the most severe class of Tbx3-null mutant embryos displays heart defects that are similar to zebrafish tbx3b morphants with respect to morphology and the degree of development, indicating that the mechanisms of AVC formation are conserved among vertebrates.
All of the mutants died during embryonic development, indicating that the conditional mutation is embryonically lethal.
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First, research on early brain development indicates that the brain develops most rapidly in the first years of life and that environmental stimulation positively affects the developing brain (Shonkoff and Phillips 2000).
Does this development indicate that the field is sunsetting or is this decline only temporary?
The development indicates that the rebels, known as the Houthis, may be determined to carve out a mini-state within Yemen, taking advantage of the weakness of the central government and the disarray in the army and security forces.
The development indicates that the government of Mali's newly elected president isn't shying away from confronting Gen. Amadou Haya Sanogo, who led the March 2012 coup and is accused of systematically torturing and executing soldiers who questioned his rise to power.
The larva and the pattern of its early development indicate that the entoprocts may be linked remotely with the annelids and other protostome phyla, but precise evolutionary relationships with other phyla are not yet clear.
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