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These results indicate that the iSG could develop according to the process of embryonic salivary gland development in vitro and that orthotopic transplantation of the iSG in vivo could promote its maturation.
Lu, J. et al. Effects of targeting SLC1A5 on inhibiting gastric cancer growth and tumor development in vitro and in vivo.
"Currently, it is impossible to accurately recapitulate human development in vitro, and there is no ethical method to obtain post-implantation stage human fetal tissue for isolating tissue and organ stem cells for regenerative medicine," they wrote.
Systems integrating architectural, physical and molecular cues will allow more systematic investigation of basic principles of tissue morphogenesis, differentiation or maintenance and will feedback to reproduce the dynamic of tissue development in vitro and form more complex tissues.
Here, we compared genetic requirements for germ cell development in vitro and in vivo.
We next performed knocked down experiments using specific ILK1 siRNA and analyzed its consequences on glioma cell proliferation and tumor development in vitro and in vivo.
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Finkbeiner, S. R. et al. Transcriptome-wide analysis reveals hallmarks of human intestine development and maturation in vitro and in vivo.
Knowledge of toxicity targets will facilitate the development of in vitro and in vivo assays to aid in identifying toxic drugs early in drug development.
The development of in vitro and in silico approaches to replace monkeys and apes in the lab ranks very highly among the priorities of many critics.
Downregulation of Nanog has recently been shown to inhibit prostate, breast and colon tumor development both in vitro and in vivo [15].
DAS181 (Fludase™) is a sialidase fusion protein in early clinical development with in vitro and in vivo preclinical activity against a variety of seasonal influenza strains and highly pathogenic avian influenza strains (A/H5N1).
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