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It has been shown that maternal mental health is associated with poorer skills development in the offspring.
Our hypothesis was that paternal stress in the preconception period could impact brain development in the offspring, leading to behavioral abnormalities later in life.
In humans, this smoking grandparent effect on asthma development in the offspring was also reported [17] but no epigenetic analyses were available in that study at the time.
This suggests that any stress experienced by the dams following exposure to the CPS schedule was of insufficient intensity to affect neurobehavioural development in the offspring.
The objective of this study was to define the effect of developmental exposure to environmentally relevant concentrations of dieldrin, on mammary tumor development in the offspring.
Caused by epigenetic modifications such as DNA methylation established during gametogenesis and maintained throughout somatic development in the offspring, genetic imprinting has been shown to play a pivotal role in regulating the formation, development, function, and evolution of complex traits and diseases [3], [4], [5], [6], [7], [8], [9], [10].
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Specifically, research models of over-nutrition have demonstrated that early dietary insults can alter gene expression and promote atherosclerotic disease development in the developing offspring [ 24].
We hypothesize that dysmetabolic programming events occurring within critical windows in development predispose the offspring to CVD and T2D as adults, and that these processes may be mediated by epigenetic processes that give rise to transgenerational inheritance.
The objective of the study was to investigate the effect of fetal programming on the development of atherosclerosis in the offspring in a mouse model.
A healthy diet in pregnancy is important for lung development and innervation in the offspring, and imbalances can lead to airway hyperreactivity independent of the postnatal diet.
Long-term changes in 5HT innervation and/or synaptic activity may play a role in the subsequent development of depression in the offspring of women who smoke during pregnancy or in adolescent smokers.
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